Tetrahydroaminoacridine (tacrine) stimulates neurosecretion at mammalian motor endplates
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منابع مشابه
Early effects of carbachol on the morphology of motor endplates of mammalian skeletal muscle fibers.
Long-term disturbance of the calcium homeostasis of motor endplates (MEPs) causes necrosis of muscle fibers. The onset of morphological changes in response to this disturbance, particularly in relation to the fiber type, is presently unknown. Omohyoid muscles of mice were incubated for 1-30 minutes in 0.1 mM carbachol, an acetylcholine agonist that causes an inward calcium current. In these mus...
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Motor neurons (MNs) are the principal neurons in the mammalian spinal cord whose activities cause muscles to contract. In addition to their peripheral axons, MNs have central collaterals that contact inhibitory Renshaw cells and other MNs. Since its original discovery >60 years ago, it has been a general notion that acetylcholine is the only transmitter released from MN synapses both peripheral...
متن کاملExpression of acetylcholine receptor isoforms at extraocular muscle endplates.
PURPOSE To determine the expression of fetal and adult acetylcholine receptor (AChR) isoforms among extraocular muscle (EOM) en plaque and en grappe endplates. METHODS Antibodies against peptide fragments of the gamma- and epsilon-subunits of the fetal and adult AChRs and alpha-bungarotoxin were used in immunofluorescence experiments to stain rat neonatal leg, adult diaphragm, and extraocular...
متن کاملWhen Do Endplates Work?
The effect of the gap between endplates and wing sections on aerodynamic lift and drag forces was investigated. This was studied in order to determine the maximum gap distance at which flow can still be considered two-dimensional, and tip effects can be neglected. A non-dimensional distance, λ, was defined as the ratio of gap distance, d, to laminar boundary layer thickness, δt,laminar , over t...
متن کاملGating properties of acetylcholine receptors at developing rat endplates.
The gating properties of acetylcholine receptors (AChRs) change during the development of rat soleus endplates. During the first 3 weeks after birth, the apparent mean channel open time (tau) decreases severalfold and the single-channel conductance (gamma) increases 50%. To better understand this phenomenon, we used a combination of noise analysis, analysis of miniature endplate currents (MEPCs...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1990
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1990.tb15834.x